Neuronal Dynamics

Sensations like "colder'' or "warmer'' are perceived at peripheral nerve endings, residing for instance on the skin or the tounge, transduced to electrical pulses and transmitted to the brain via nerve conduction. Coding of the information involves a modulation of the temporal distance between nerve pulses (interspike intervals). We investigate how changing temperatures modify the neuronal dynamics in a mathematical model (HuberBraun model) of a thermoreceptor. Noise is an integral part of every biological system. Quite often this inherent noise is utilized for an optimal information transfer. We develop mathematical models and employ numerical methods to understand and describe the beneficial influence of noise. In many pathophysiological disorders like Parkinson"s disease neuronal synchronisation plays a decisive role. Through mathematical models we investigate conditions that either build or destroy a synchronisation of coupled neurons.